What is phenobarbital half-life?

Phenobarbital half-life is the time it takes for half of the drug to be eliminated from the body. The half-life of phenobarbital can vary based on factors such as age, sex, weight, kidney function, liver function, and other medications taken. In healthy adults, the half-life of phenobarbital is typically between 50-150 hours. However, in newborns and infants, the half-life can be longer, up to 120-180 hours. This is because their liver and kidney functions are not yet fully developed, and they have a larger volume of distribution of phenobarbital due to their higher body water content. Overall, understanding the half-life of phenobarbital is important in determining dosages and monitoring for potential side effects.